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Anal Chem 84:36143620

R Amino acid conjugation: The two-step reaction involves: (1) mitochondrial medium-chain acyl-CoA ligase (HXM-A and HXM-B) activating the carboxylic acid substrate with CoA in an ATP-dependent reaction to form an acyl-CoA thioester, and (2) GLYAT (glycine N-acyltransferase) transferring the acyl group from CoA to the alpha-amino group of glycine via a ping-pong mechanism

Despite promising preclinical outcomes, MSC therapy for AGA faces several critical challenges in clinical translation

A balanced diet rich in vitamin B12 and other nutrients, along with regular physical activity, can support overall health and help maintain adequate B12 levels

doi: 10.1186/S12933-022-01623-4 92 KellDBLaubscherGJPretoriusE